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The amount of medicine that you take depends on the strength of the medicine. She has to check her laptop several times a day to remember what day it is. The physician should periodically reassess the usefulness of the drug for the individual patient. Now, I have learned these drugs stay in the body for days, if not weeks! The mean half-life of unconjugated Lorazepam in human plasma is about 12 hours and for its major metabolite, Lorazepam glucuronide, about 18 hours. Even with intravenous sedation, there are still those who will require deeper levels of sedation, deep sedation, or general anesthesia, if dental care is to be provided successfully.