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Lorazepam is rapidly conjugated at its 3-hydroxy group into Lorazepam glucuronide which is then excreted in the urine. Patients should be informed of the pharmacological effects of the drug, including sedation, relief of anxiety, and lack of recall, the duration of these effects about 8 hours , and be apprised of the risks as well as the benefits of therapy. Perrigo Company Pfizer Inc. Elderly or debilitated patients may be more susceptible to the sedative effects of Lorazepam. Ordinarily, Lorazepam Injection should not be used during pregnancy except in serious or life-threatening conditions where safer drugs cannot be used or are ineffective. Although analyses failed to detect an effect of age, sex, or race on the effectiveness of lorazepam in status epilepticus, the numbers of patients evaluated were too few to allow a definitive conclusion about the role these factors may play. The use of benzodiazepines, like Lorazepam Injection, is ordinarily only one step of a complex and sustained intervention which may require additional interventions e.