Tag Archives: Researchers

Researchers quantify Cas9-caused off-target mutagenesis in mice

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results from a research collaboration including Lauryl Nutter, PhD, Senior Director, Science and Technology Development at The Centre for Phenogenomics at The Hospital for Sick Children (SickKids) in… Read More »

Multiple sclerosis could be stopped in the next DECADE, researchers say

Multiple sclerosis could be stopped in the next DECADE, researchers say as they hail scientific breakthroughs that ‘pave the way to wiping out the condition’ Scientists say range of medications will be in late stage trials by as early as 2025 This year saw breakthrough with blood sugar and cholesterol-lowering drugs  Currently only medications available for sufferers… Read More »

Mass. General researchers develop 3-D ‘mini-gut’ model to study response to gluten

In pursuit of a novel tool for the research and treatment of celiac disease, scientists at the Mucosal Immunology and Biology Research Center (MIBRC) at Massachusetts General Hospital (MGH) have validated the use of intestinal organoids. These 3-D tissue cultures are miniature, simplified versions of the intestine produced in vitro. Taking tissue from duodenal biopsies of celiac… Read More »

Harvard researchers look toward nature to beat cancer

Dramatic responses in cancerous mice that received the vaccine spurred Mooney and his collaborators at the Dana-Farber Cancer Institute (DFCI) to start a phase 1 clinical trial with support from both institutes, to see if it had the same effect in human patients. This kind of study is usually undertaken by hospitals and pharmaceutical companies,… Read More »

Epidemic of autoimmune diseases pushes researchers in new direction

The immune system normally defends the body against everything from microscopic viruses to meters-long parasitic worms. But sometimes, it sets its sights on the wrong target: the body’s own cells. Autoimmunity problems cause many different diseases, depending on which cells are targeted. In Type 1 diabetes, it’s beta cells. Beta cells are located in the… Read More »