Medscape - Anxiety, status epilepticus, sedation-specific dosing for Ativan, severe impairment or renal failure; IV/IM (prolonged periods or high doses): Monitor; risk of .. Menopause Triggers Metabolic Brain Changes Linked to Alzheimer's. Oral and parenteral benzodiazepine; glucuronidated to inactive metabolites; used In residents meeting the criteria for treatment, the dose of lorazepam should not . dosage information not available; the dose required is dependent on route of Lorazepam is not recommended for use in patients with primary depressive. Conjugation with glucuronic acid to form inactive lorazepam glucuronide is the major metabolic pathway. Seventy (70) to 75% of the administered dose is.